Blar i forfatter "Domingues, Sara"

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    • Identical Miniature Inverted Repeat Transposable Elements Flank Class 1 Integrons in Clinical Isolates of Acinetobacter spp. 

      Domingues, Sara; Toleman, Mark A.; Nielsen, Kåre M.; da Silva, Gabriela J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Miniature inverted repeat transposable elements (MITEs) have been identified flanking class 1 integrons. We have identified and characterized a 439-bp MITE-like structure in seven Acinetobacter species isolates from Portugal and Brazil. The complete sequence similarity of the elements and flanking regions suggests that MITEs may act as mobilizable vectors for the dissemination of integrons.

    • Involvement of aph(3')-IIa in the formation of mosaic aminoglycoside resistance genes in natural environments 

      Woegerbauer, Markus; Kuffner, Melanie; Domingues, Sara; Nielsen, Kaare Magne (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-19)
      Intragenic recombination leading to mosaic gene formation is known to alter resistance profiles for particular genes and bacterial species. Few studies have examined to what extent aminoglycoside resistance genes undergo intragenic recombination. We screened the GenBank database for mosaic gene formation in homologs of the aph(3′)-IIa (nptII) gene. APH(3′)-IIa inactivates important aminoglycoside ...

    • Natural Transformation Facilitates Transfer of Transposons, Integrons and Gene Cassettes between Bacterial Species 

      Domingues, Sara; Harms, Klaus; Fricke, W. Florian; Johnsen, Pål Jarle; da Silva, Gabriela J.; Nielsen, Kåre M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      We have investigated to what extent natural transformation acting on free DNA substrates can facilitate transfer of mobile elements including transposons, integrons and/or gene cassettes between bacterial species. Naturally transformable cells of Acinetobacter baylyi were exposed to DNA from integron-carrying strains of the genera Acinetobacter, Citrobacter, Enterobacter, Escherichia, Pseudomonas, ...